A 50-Year-Old Man with Deteriorating Cognitive Function and Impaired Movement

A50-year-old man was referred to the Cognitive Function Clinic with a 12to 18-month history of deterioration in his memory. The symptoms reported by the patient and his wife included forgetting what he was supposed to be doing, occasional disorientation in place, misplacing objects, and word-finding difficulties, all of which had affected his occupational function as a high school teacher. His past medical history was unremarkable. In the family history, his mother was said to have had Alzheimer disease (AD) in her fifties and died in her sixties, but no further details were available to confirm or refute this. The patient’s neurological examination was normal.